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M9460207.TXT
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1994-06-12
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Document 0207
DOCN M9460207
TI Seroprevalence of human T-lymphotropic virus, hepatitis C virus, and
human immunodeficiency virus in Asian American potential bone marrow
donors.
DT 9408
AU Sun M; Chao KH; Modahl LE; Leoung G; Khayam-Bashi H; Ng VL; Murphy EL;
Department of Medicine, University of California, San Francisco.
SO Transfusion. 1994 Apr;34(4):344-8. Unique Identifier : AIDSLINE
MED/94233584
AB BACKGROUND: Asian Americans are generally underrepresented both as
volunteer blood and bone marrow donors. STUDY DESIGN AND METHODS: To
investigate the risk of transfusion transmission of viruses that is
associated with increasing participation by Asian American donors,
antibodies to human T-lymphotropic virus (HTLV), hepatitis C, and human
immunodeficiency virus in Asian American volunteers recruited as
potential bone marrow donors were measured. A total of 1354 Asian
Americans were enrolled in the study, of whom 54 percent were Chinese,
26 percent Japanese, 9 percent Filipino, 4 percent Korean, 3 percent
Indian, and 5 percent of other Asian or mixed Asian and other ethnicity.
The majority of the study population was aged 20 through 49 and of high
socioeconomic status, as indicated by education and income. Viral
antibodies were measured with both screening enzyme-linked immunosorbent
assays and supplemental testing, and polymerase chain reaction was used
to resolve discrepant HTLV results. RESULTS: Confirmed seroprevalence
rates for HTLV were 0.15 percent with one manufacturer's Western blot
and 0.3 percent with the other; however, no sample was positive for HTLV
types I or II in polymerase chain reaction. Confirmed seroprevalence to
hepatitis C virus was 0.5 percent. No subject was seropositive for human
immunodeficiency virus. CONCLUSION: On the basis of the moderate size
and high education level of this study population, it is concluded that
Asian American volunteer bone marrow donors do not pose a greater risk
for transmission of HTLV type I or II, human immunodeficiency virus, or
hepatitis C virus than does the average American blood donor.
DE Adolescence Adult Antibodies, Viral/BLOOD Asia/ETHNOLOGY *Bone
Marrow Transplantation Hepatitis C Human *HIV Seroprevalence HTLV-I
Infections/EPIDEMIOLOGY HTLV-II Infections/EPIDEMIOLOGY Middle Age
Prevalence Support, Non-U.S. Gov't *Tissue Donors United
States/EPIDEMIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).